2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Aurora Kinase Apoptosis
  4. Aurkin A

Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer.

For research use only. We do not sell to patients.

Aurkin A Chemical Structure

Aurkin A Chemical Structure

CAS No. : 1534060-58-6

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Description

Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2].

In Vitro

Aurkin A (10-1000 μM; 2 h) mislocalizes Aurka from the mitotic spindle microtubules in HeLa cells (EC50: 85 μM) and reduces T288 autophosphorylation levels (EC50: 135 μM)[1].
Aurkin A (0-200 µM; 3-5 days) can disrupt Alisertib (HY-10971)-induced polyploidy and increase apoptosis in U2932 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aurkin A Related Antibodies
In Vivo

Aurkin A (30 mg/kg; 15 times, 4 weeks in total) significantly reduces Alisertib (HY-10971)-induced polyploidy formation in mice subcutaneously implanted with VAL cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice treated VAL cells[2]
Dosage: 30 mg/kg
Administration: Once a day for five days a week. After two weeks, treatment was then withheld for a week, followed by another five-day-a-week treatment cycle
Result: Significantly reduced the proportion of polyploid cells induced by alisertib from 43.6% to 16.1%, compared to the alisertib-only group.
Molecular Weight

346.15

Formula

C16H9BrFNO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C2C=CC=C(F)C2=NC(C3=CC(Br)=CC=C3)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Aurkin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurkin A1534060-58-6Aurora KinaseApoptosisAllostericVAL cellsHeLa cellsU2932 cellsInhibitorinhibitorinhibit

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