2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis Topoisomerase
  4. Apoptosis inducer 54

Apoptosis inducer 54 is an apoptosis inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer.

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Apoptosis inducer 54

Apoptosis inducer 54 Chemical Structure

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Apoptosis inducer 54 Related Antibodies

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Description

Apoptosis inducer 54 is an apoptosis inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer[1].

In Vitro

Apoptosis inducer 54 (compound 9f) shows potent antiproliferative effects, with IC50 values of 16.1 μM and 19.7 μM against A549 and SW480, respectively. Apoptosis inducer 54 shows significant selectivity towards A549 and SW480 cancer cells compared to the normal MRC-5[1].
Apoptosis inducer 54 (16.1 μM; 24-48 h; A549) induces early and late apoptosis in a time-dependent manner[1].
Apoptosis inducer 54 (16.1 μM; 24-48 h; A549) shows cell cycle arrest at the S phase in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 54 Related Antibodies

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 16.1 μM
Incubation Time: 24 h, 48 h
Result: Significantly induced early and late apoptosis in A549 cells after 48 h.

Cell Cycle Analysis[1]

Cell Line: A549
Concentration: 16.1 μM
Incubation Time: 24 h, 48 h
Result: Showed a significant increase in the number of cells in the S phase, along with a significant reduction in the number of cells in the G0/G1 phase, and a non-significant decrease in the G2/M phase.
Molecular Weight

558.59

Formula

C29H30N6O6
SMILES

O=C(NC1=CC=C(OC)C=C1OC)CN2N=NC(CN3C(C4=CC(OC)=C(OC)C(OC)=C4)=NC5=CC=CC=C35)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptosis inducer 54 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 54Apoptosis inducer54Apoptosis inducer-54ApoptosisTopoisomerasetopoisomerase II-DNA,Apoptosis Inducer,cell cycle arrest,lung cancer and colon cancerInhibitorinhibitorinhibit

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