2. PROTAC Neuronal Signaling GPCR/G Protein
  3. Molecular Glues Adrenergic Receptor
  4. AP-7-168

AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR). AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma.

For research use only. We do not sell to patients.

AP-7-168

AP-7-168 Chemical Structure

CAS No. : 2816062-15-2

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AP-7-168 Related Antibodies

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Description

AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR). AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma[1].

IC50 & Target[1]

Beta-2 adrenergic receptor

 

In Vitro

AP-7-168 (0.03-100 μM, 1 h) promotes β2AR homodimerization in HEK293 cells with a pEC50 of 5.93[1].
AP-7-168 (10 μM) inhibits β-arrestin2 recruitment and GRK5-mediated β2AR phosphorylation in β2AR-expressing cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AP-7-168 Related Antibodies
Molecular Weight

433.29

Formula

C20H19BrF2N4
CAS No.
SMILES

FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F
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References
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AP-7-168 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP-7-1682816062-15-2Molecular GluesAdrenergic ReceptorBeta Receptoradrenergic receptorHEK293GRK5homodimerizationβ-arrestin2Inhibitorinhibitorinhibit

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