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  5. HAUSP/USP7 Antibody (YA4412)

HAUSP/USP7 Antibody (YA4412)

Cat. No.: HY-P84715
User Guide for Antibodies Technical Support

HAUSP/USP7 Antibody (YA4412) is a mouse-derived and non-conjugated IgG2b antibody, targeting to USP7. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

HAUSP/USP7 Antibody (YA4412) is a mouse-derived and non-conjugated IgG2b antibody, targeting to USP7. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rat, monkey.
Background

HAUSP is a hydrolase that deubiquitinates various target proteins, including ARMC5, FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5, and DAXX. In collaboration with DAXX, it prevents MDM2 self-ubiquitination and enhances MDM2's E3 ligase activity toward p53/TP53, promoting p53/TP53 ubiquitination and proteasomal degradation. HAUSP also deubiquitinates p53/TP53 to prevent its degradation and enhances p53/TP53-dependent transcriptional regulation, cell growth repression, and apoptosis. Additionally, HAUSP is involved in maintaining DNA methylation, transcription-coupled nucleotide excision repair (TC-NER), regulatory T-cell (Treg) suppressive capacity, circadian clock periodicity, neural progenitor cell maintenance, and WASH-dependent actin polymerization. During viral infections, HAUSP contributes to the stabilization and trans-activation capability of herpesvirus 1 ICP0/VMW110 and interacts with Epstein-Barr virus EBNA1 to promote PML protein ubiquitination and degradation.
Gene ID
SwissProt ID
Synonyms
TEF1; HAUSP; HAFOUS
Molecular Weight

Predicted band size: 128 kDa; Observed band size: 135 kDa
Purity

affinity purified.
Conjugation

Non-conjugated
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Host

Mouse
Reactivity

Human, Mouse, Rat, Monkey
Dilution Ratio

WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000
Application

WB, IHC-P, ICC/IF, FC, ELISA
Appearance

Liquid
Formulation

Supplied in PBS with 0.05% sodium azide
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG2b
Immunogen

Purified recombinant fragment of human USP7 (AA:1-208) expressed in E. Coli.
Documentation
User Guide for Antibodies (1077 KB)

HAUSP/USP7 Antibody (YA4412) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HAUSP/USP7 Antibody (YA4412)
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