USP13 Antibody (YA2367)

USP13 Antibody (YA2367) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2367), targeting USP13, with a predicted molecular weight of 97 kDa (observed band size: 97 kDa). USP13 Antibody (YA2367) can be used for WB, ICC/IF, IP experiment in human background.

The USP13 Protein, as outlined in this description, serves as a versatile deubiquitinase involved in various cellular processes, including autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression, and DNA damage response. It mediates the deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10, exerting influence on critical pathways. In the regulation of autophagy and p53/TP53 levels, USP13 participates in a complex interplay by deubiquitinating BECN1, stabilizing PIK3C3/VPS34-containing complexes, and forming a deubiquitination complex with NEDD4 to promote autophagy. Additionally, it regulates the stability of USP10, influencing the intricate balance of p53/TP53. USP13 contributes to endoplasmic reticulum-associated degradation (ERAD) by deubiquitinating SKP2 and UBL4A. Furthermore, it plays essential roles in maintaining genomic stability, DNA replication checkpoint activation through regulation of RAP80 and TOPBP1, and modulation of interferon signaling by deubiquitinating STAT1 and STING1. The multifunctional nature of USP13 underscores its significance in orchestrating diverse cellular processes with implications for cellular homeostasis and response to external stimuli.

Q92995

Predicted band size: 97 kDa; Observed band size: 97 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/20

WB, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human USP13