2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. SLFN12 Antibody (YA5976)

SLFN12 Antibody (YA5976)

Cat. No.: HY-P86284
User Guide for Antibodies Technical Support

SLFN12 Antibody (YA5976) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLFN12. It can be applicated for WB, FC assays, in the background of human.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

SLFN12 Antibody (YA5976) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLFN12. It can be applicated for WB, FC assays, in the background of human.
Background

SLFN12 is a ribonuclease involved in an E2/17β-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the cytosolic PDE3A/SLFN12 complex, promoting SLFN12 dephosphorylation and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway may be relevant in tissues with high E2 concentrations, such as during placenta remodeling. Additionally, SLFN12 might play a role in cell differentiation. By similar studies, its function is linked to E2 signaling and apoptosis regulation.
Gene ID
SwissProt ID
Synonyms
SLFN12; Ribonuclease SLFN12 ; Schlafen family member 12;
Molecular Weight

Observed band size: 64 kDa
Purity

Protein A
Conjugation

Non-conjugated
Modification

Unmodified
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Monoclonal
Host

Rabbit
Reactivity

Human
Dilution Ratio

WB: 1:1000-5000; FC 1:100-300
Application

WB, FC
Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Documentation
User Guide for Antibodies (1077 KB)

SLFN12 Antibody (YA5976) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SLFN12 Antibody (YA5976)
Cat. No.:
HY-P86284
Quantity:
MCE Japan Authorized Agent:

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Country or Region *

Email Address *

     

Phone Number *

 

Organization Name *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.