POU3F2 Antibody (YA3865)

POU3F2 Antibody (YA3865) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POU3F2.

Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) is an enzyme characterized by its broad specificity. It functions as a negative regulator of TGF-beta signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4 and subsequent nuclear export. This enzymatic activity ultimately terminates the TGF-beta-mediated signaling pathway. Additionally, PPM1A dephosphorylates PRKAA1 and PRKAA2, contributing to the regulation of cellular processes associated with AMP-activated protein kinase. Furthermore, PPM1A plays a crucial role in the termination of TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. The diverse substrate specificity of PPM1A underscores its importance in modulating key signaling pathways, highlighting its regulatory functions in cellular responses to TGF-beta and TNF-alpha signaling (

P20265

Predicted band size: 47 kDa; Observed band size: 47 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal Antibody

Mouse

Human

WB: 1:250; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human POU3F2 (AA: 214-362) expressed in E. Coli.