PDGFR alpha Antibody (YA6353)

PDGFR alpha Antibody (YA6353) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDGFR-α. It can be applicated for WB assays, in the background of human, mouse, rat.

CD140a is a tyrosine-protein kinase that functions as a cell-surface receptor for PDGFA, PDGFB, and PDGFC, playing pivotal roles in embryonic development, cell proliferation, survival, and chemotaxis regulation. Its context-dependent actions include promoting or inhibiting cell proliferation/migration. It is essential for bone marrow-derived mesenchymal stem cell differentiation, embryonic skeleton development, cephalic closure, gastrointestinal mucosa formation, mesenchymal cell recruitment, and intestinal villi development. It contributes to wound healing via chemotaxis/migration and regulates platelet activation, granule secretion, and thrombin-induced aggregation. Ligand binding (PDGFA/PDGFB homo/heterodimers or PDGFC homodimers) triggers diverse signaling cascades modulated by PDGFRA/PDGFRB heterodimerization. It phosphorylates PIK3R1 (activating AKT1), PLCG1 (generating DAG/IP3 for Ca2+ mobilization and PKC activation), and PTPN11, while activating HRAS, MAPK1/ERK2/MAPK3/ERK1, and STAT1/STAT3/STAT5. Signaling is attenuated by phosphatase-mediated dephosphorylation and receptor internalization.

P16234

Predicted band size: 117 kDa

affinity purified.

Cell membrane; Single-pass type I membrane protein. Note=The activated receptor is rapidly internalized and degraded.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

WB: 1:1000-2000

WB

Liquid

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

A synthesized peptide derived from human PDGFR alpha aa 1050-1089