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  4. NME2 Antibody (YA3884)

NME2 Antibody (YA3884)

Cat. No.: HY-P84187
User Guide for Antibodies Technical Support

NME2 Antibody (YA3884) is a mouse-derived and non-conjugated IgG1 antibody, targeting to NME2. It can be applicated for WB, IHC-P, ELISA assays, in the background of human.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

NME2 Antibody (YA3884) is a mouse-derived and non-conjugated IgG1 antibody, targeting to NME2. It can be applicated for WB, IHC-P, ELISA assays, in the background of human.

Background

NME2 plays a major role in the synthesis of nucleoside triphosphates other than ATP. It transfers the ATP gamma phosphate to the NDP beta phosphate via a ping-pong mechanism, utilizing a phosphorylated active-site intermediate (By similarity). It negatively regulates Rho activity by interacting with AKAP13/LBC. As a transcriptional activator of the MYC gene, NME2 binds DNA non-specifically, particularly to single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, but does not bind duplex NHE III(1). Additionally, NME2 exhibits G-quadruplex (G4) DNA-binding activity, independent of its nucleotide-binding and kinase activity, binding both folded and unfolded G4 with low nanomolar affinity and stabilizing folded G4 structures. NME2 also displays histidine protein kinase activity.

Gene ID
SwissProt ID
Synonyms
PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2
Molecular Weight

Predicted band size: 17 kDa; Observed band size: 17 kDa

Purity

affinity purified.

Conjugation

Non-conjugated

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Host

Mouse

Reactivity

Human

Dilution Ratio

WB: 1/500-1/1000; IHC: 1/200-1/1000; ELISA: 1/10000

Application

WB, IHC-P, ELISA

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG1

Immunogen

Purified recombinant fragment of human NME2 (AA: FULL(1-152)) expressed in E. Coli.

Documentation

NME2 Antibody (YA3884) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NME2 Antibody (YA3884)
Cat. No.:
HY-P84187
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