NDRG1 Antibody (YA5863)

NDRG1 Antibody (YA5863) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NDRG1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

NDRG1, a stress-responsive protein, plays a crucial role in hormone responses, cell growth, and differentiation, functioning as a tumor suppressor in various cell types. While necessary for p53/TP53-mediated caspase activation and apoptosis, it alone is not sufficient for these processes. NDRG1 contributes to cell trafficking, particularly in Schwann cells, and is essential for the maintenance and development of the peripheral nerve myelin sheath. Additionally, it is required for the vesicular recycling of CDH1 and TF and may participate in lipid trafficking. Notably, NDRG1 shields cells from spindle disruption damage and functions in the p53/TP53-dependent mitotic spindle checkpoint, regulating microtubule dynamics and preserving euploidy. Its interaction with membrane-bound RAB4A is integral to vesicular recycling of CDH1, further emphasizing its diverse roles in cellular processes.

Q92597

Predicted band size: 43 kDa; Observed band size: 48 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:2000-1:10000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG