MUC4 Antibody (YA5732)

MUC4 Antibody (YA5732) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MUC4. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human.

MUC4 is a membrane-bound mucin, a family of highly glycosylated proteins that form the major component of mucus covering epithelial surfaces. These glycoproteins play vital roles in epithelial protection, renewal, and differentiation. MUC4 regulates cellular behavior through anti-adhesive effects on cell-cell and cell-extracellular matrix interactions while acting as an intramembrane ligand for ERBB2. It critically influences epithelial cell proliferation and differentiation by inducing ERBB2-specific phosphorylation. In polarized epithelial cells, MUC4 segregates ERBB2 from other ERBB receptors, preventing its coreceptor function. Interaction with ERBB2 enhances CDKN1B expression, whereas the MUC4-ERBB2-ERBB3-NRG1 complex downregulates CDKN1B, suppressing apoptosis and stimulating proliferation. Its pro-tumorigenic effect likely stems primarily from apoptosis repression rather than direct proliferation promotion.

Q99102

Predicted band size: 231 kDa;

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

IHC: 1:200-400; ICC/IF: 1:50-200; ELISA: 1:500-5000

IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Synthesized peptide derived from human MUC4 AA range: 2000-2100