MECP2 Antibody (YA4069)

MECP2 Antibody (YA4069) is a mouse-derived and non-conjugated IgG1 antibody, targeting to MECP2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human.

The MeCP2 protein functions as a chromosomal entity with a distinctive ability to bind specifically to methylated DNA, targeting individual methyl-CpG pairs independently of flanking DNA sequences. Operating as a mediator of transcriptional repression, MeCP2 engages in interactions with histone deacetylase and the corepressor SIN3A. Moreover, it demonstrates dual binding capabilities, associating with both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, exhibiting a notable preference for 5-methylcytosine (5mC). The versatility of MeCP2 is further emphasized by its interactions with FNBP3, CDKL5, ATRX, NCOR2, TBL1XR1, and TBL1X, each interaction contributing to various cellular processes, including the recruitment of co-repressor complexes and the orchestration of heterochromatin organization. This multifaceted functionality underscores the pivotal role of MeCP2 in epigenetic regulation and the modulation of gene expression.

P51608

Predicted band size: 52 kDa; Observed band size: 52 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human MECP2 (AA: 7-148) expressed in E. Coli.