JAK3 Antibody (YA5408)

JAK3 Antibody (YA5408) is a mouse-derived and non-conjugated monoclonal antibody, targeting to JAK3. It can be applicated for IHC-P assays, in the background of human, mouse, rat.

JAK3 is a non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. It mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cell development. In the cytoplasm, JAK3 plays a pivotal role in signal transduction by associating with type I receptors that share the common γ subunit, such as IL2R, IL4R, IL7R, IL9R, IL15R, and IL21R. Following ligand binding to cell surface receptors, JAK3 phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. It then phosphorylates the recruited STATs proteins, which subsequently form homodimers or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2 binding to IL2R, JAK1 and JAK3 bind to the IL2R β (IL2RB) and γ (IL2RG) subunits, inducing tyrosine phosphorylation of both receptor subunits. STAT5A and STAT5B are then recruited, phosphorylated, and activated by JAK1 and JAK3. The activated, dimerized STAT5 translocates to the nucleus to promote transcription of specific target genes in a cytokine-specific manner.

P52333

Observed band size: 125 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC: 1:50-200

IHC-P

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human JAK3