HES1 Antibody (YA5777)

HES1 Antibody (YA5777) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HES1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

Hes1 is a transcriptional repressor targeting genes that require bHLH proteins for their transcription. It may negatively regulate myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 binds DNA with high affinity to N-box motifs (5'-CACNAG-3') and with low affinity to E-box motifs (5'-CANNTG-3') (By similarity). Additionally, Hes1 may play a role in the FA core complex's response to DNA cross-link damage, ensuring the stability and nuclear localization of FA core complex proteins, as well as promoting FANCD2 monoubiquitination upon DNA damage.

Q14469

Predicted band size: 30 kDa; Observed band size: 30 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:4000-1:20000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG