GSK3 alpha/beta Antibody (YA1862)

Cat. No.: HY-P82117: Data Sheet User Guide for Antibodies
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GSK3 alpha/beta Antibody (YA1862) is a non-conjugated IgG antibody, targeting GSK3 alpha/beta, with a predicted molecular weight of 51 kDa (observed band size: 51,47 kDa). GSK3 alpha/beta Antibody (YA1862) can be used for WB experiment in human, rat, hamster background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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GSK3 alpha/beta Antibody (YA1862) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	GSK3 alpha/beta Antibody (YA1862) is a non-conjugated IgG antibody, targeting GSK3 alpha/beta, with a predicted molecular weight of 51 kDa (observed band size: 51,47 kDa). GSK3 alpha/beta Antibody (YA1862) can be used for WB experiment in human, rat, hamster background.
Background	GSK3α protein, a constitutively active kinase, plays a crucial role as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling, and transcription factor and microtubule regulation. It exerts its regulatory function by phosphorylating and inactivating key targets such as glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC, and AXIN1. Primed phosphorylation is a requisite for the majority of its substrates. GSK3α contributes to insulin's control of glycogen synthesis by inhibiting GYS1 activity and thus glycogen synthesis, particularly in the liver. Additionally, it is implicated in the regulation of insulin resistance and plays a role in Wnt signaling by modulating the level and transcriptional activity of nuclear CTNNB1/beta-catenin. GSK3α also participates in amyloid precursor protein (APP) processing associated with Alzheimer's disease, regulates replication in pancreatic beta-cells, and is crucial for the establishment of neuronal polarity and axon outgrowth. Furthermore, it controls cell apoptosis in response to growth factor deprivation, negatively regulates the extrinsic apoptotic signaling pathway, and promotes the formation of an anti-apoptotic complex at death receptors. GSK3α also acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, promoting acetylation of key autophagy regulators. Additionally, it negatively regulates the mTORC2 complex by phosphorylating RICTOR, leading to its ubiquitination and degradation.
Gene ID	2931 [NCBI]
SwissProt ID	P49840
Synonyms	Serine/threonine-protein kinase GSK3A
Molecular Weight	Predicted band size: 51 kDa; Observed band size: 51,47 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Rat, Hamster
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthetic peptide of human GSK3 alpha
Database	Entrez Gene: 2931 Human ; 2932 Human ; 50686 Rat 84027 SwissProt: P49840 Human ; P49841 Human ; P18265 Rat P18266 OMIM: 606784 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

GSK3 alpha/beta Antibody (YA1862) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GSK3 alpha/beta Antibody (YA1862)

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