ERK5 Antibody (YA5416)

ERK5 Antibody (YA5416) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ERK5. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

ERK 5 is a protein kinase involved in various cellular processes such as proliferation, differentiation, and cell survival. Its upstream activator is the MAPK kinase MAP2K5. Upon activation, ERK 5 translocates to the nucleus and phosphorylates multiple downstream targets, including MEF2C. EGF activates ERK 5 through a Ras-independent but MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, ERK 5 acts as a negative regulator of apoptosis in cardiomyocytes by interacting with STUB1/CHIP and promoting STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (by similar). ERK 5 may play a role in muscle cell differentiation and is important for endothelial function and blood vessel integrity. MAP2K5 and ERK 5 specifically interact with each other but not with the MEK1/ERK1 or MEK2/ERK2 pathways. ERK 5 phosphorylates SGK1 at Ser-78, which is required for growth factor-induced cell cycle progression. Additionally, ERK 5 regulates p53/TP53 by disrupting the PML-MDM2 interaction.

Q13164

Observed band size: 115 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC1:50-200; WB: 1:1000-2000

IHC-P, WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human ERK5