Cyclin H Antibody (YA5224)

Cyclin H Antibody (YA5224) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H. It can be applicated for WB, IP assays, in the background of human.

Cyclin H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6 through threonine phosphorylation. When associated with the core-TFIIH basal transcription factor, the CAK complex phosphorylates the serine residues in the C-terminal domain (CTD) of RNA polymerase II's largest subunit (POLR2A), enabling promoter escape and transcriptional elongation. Cyclin H is involved in cell cycle control and RNA polymerase II-mediated transcription, with its expression and activity remaining constant throughout the cell cycle.

P51946

Observed band size: 38 kDa; Observed band size: 38 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:1000; IP: 1:20

WB, IP

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant human Cyclin H protein fragments expressed in E.coli.