Cyclin H Antibody (YA5116)

Cyclin H Antibody (YA5116) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H. It can be applicated for WB assays, in the background of human, mouse, rat, dog, pig.

Cyclin H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) complex. CAK activates cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6 through threonine phosphorylation. When associated with the core-TFIIH basal transcription factor, the CAK complex phosphorylates the serine residues in the C-terminal domain (CTD) of RNA polymerase II's largest subunit (POLR2A), enabling promoter escape and transcriptional elongation. Cyclin H is involved in cell cycle control and RNA polymerase II-mediated transcription, with its expression and activity remaining constant throughout the cell cycle.

P51946

Predicted band size: 38 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat, Dog, Pig

WB: 1:1000-1:2000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human Cyclin H protein fragments expressed in E.coli.