Cyclin D3/CCND3 Antibody (YA4807)

Cyclin D3/CCND3 Antibody (YA4807) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin D3. It can be applicated for WB, ELISA assays, in the background of human, mouse.

Cyclin D3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits retinoblastoma (RB) protein family members, including RB1, thereby regulating the cell cycle during G(1)/S transition. Phosphorylation of RB1 triggers the dissociation of the transcription factor E2F from the RB/E2F complex, leading to the transcription of E2F target genes essential for G(1) phase progression. Cyclin D3-CDK4 complexes serve as key integrators of mitogenic and antimitogenic signals. Additionally, Cyclin D3 forms part of the ternary complex cyclin D3/CDK4/CDKN1B, which is required for the nuclear translocation and activity of the cyclin D-CDK4 complex. Cyclin D3 also exhibits CDK4-independent transcriptional coactivator activity in collaboration with ATF5.

P30281

Predicted band size: 33 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human Cyclin D3 expressed in E. Coli.