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  4. Monoclonal Antibodies
  5. Aldose Reductase Antibody (YA1083)

Aldose Reductase Antibody (YA1083)

Cat. No.: HY-P81338
User Guide for Antibodies Technical Support

Aldose Reductase Antibody (YA1083) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aldose Reductase.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Aldose Reductase Antibody (YA1083) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aldose Reductase.
Background

AKR1B1, a versatile enzyme, catalyzes the NADPH-dependent reduction of a diverse array of carbonyl-containing compounds to their respective alcohols. It exhibits enzymatic activity towards endogenous metabolites, including aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids, and xenobiotics substrates. As a key enzyme in the polyol pathway, AKR1B1 plays a critical role in hyperglycemia by catalyzing the reduction of glucose to sorbitol. The enzyme also reduces steroids and their derivatives, prostaglandins, and displays low activity toward retinals. Additionally, AKR1B1 is involved in the detoxification of dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal, and their glutathione-conjugate carbonyls (GS-carbonyls). Notably, it catalyzes the reduction of various phospholipid aldehydes generated from the oxidation of phosphatidylcholine and phosphatidylethanolamides, further emphasizing its broad substrate specificity and its integral role in cellular detoxification processes.
Gene ID
SwissProt ID
Synonyms
AR; ADR; ALR2; ALDR1
Molecular Weight

Predicted band size: 36 kDa; Observed band size: 36 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Mouse Monoclonal Antibody
Clonality

Monoclonal
Host

Mouse
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1:500-1:1000
Application

WB
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG1
Sensitivity

Endogenous
Immunogen

Purified recombinant human AKR1B1 protein fragments expressed in E.coli.
Database

Entrez Gene: 231 Human ; 11677 Mouse ; 24192 Rat

SwissProt: 15121 Human ; P45376 Mouse ; P07943 Rat

OMIM: 103880 Human

Documentation
User Guide for Antibodies (1077 KB)

Aldose Reductase Antibody (YA1083) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aldose Reductase Antibody (YA1083)
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HY-P81338
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