2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Rat CD8α Antibody (OX-8)

Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8+ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma.

For research use only. We do not sell to patients.

Anti-Rat CD8α Antibody (OX-8)

Anti-Rat CD8α Antibody (OX-8) Chemical Structure

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Description

Anti-Rat CD8α Antibody (OX-8) is an anti-rat CD8α IgG1 monoclonal antibody. Anti-Rat CD8α Antibody (OX-8) can deplete CD8+ T cells. Anti-Rat CD8α Antibody (OX-8) can enhance airway remodeling. Anti-Rat CD8α Antibody (OX-8) can be used for researches on allergic conditions and infections such as RHV-rn1 virus infection and asthma[1][2].

Isotype

Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Rat
IC50 & Target

CD8α
In Vivo

Anti-Rat CD8α Antibody (OX-8) (0.2-0.5 mg, i.v., on day -2, 5 and 12) significantly prolongs the duration of viremia in Lewis rats with a RHV-rn1 virus infection model[1].
Anti-Rat CD8α Antibody (OX-8) (250 μg, i.p., on day 13, 19 and 25) significantly enhances airway remodeling in male Brown Norway rats with an Ovalbumin (OVA) (HY-W250978) induced asthma model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats (7-8 weeks) with a RHV-rn1 virus infection model[1]
Dosage: 0.5 mg for first-dose, 0.2 mg for subsequent doses
Administration: Intravenous injection (i.v.), on day -2, 5 and 12
Result: Significantly prolonged the duration of viral infection.
Decreased the number of CD8+ T cells.
Animal Model: OVA (1 mg) induced male Brown Norway rats (6-7 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 13, 19 and 25
Result: Increased PCNA positive cells.
Increased PAS positive cells.
Increased the positive area of α-SMA.
Gene ID

12525  [NCBI]

Accession

P01731-1
Molecular Weight

150 kDa

SMILES

[Anti-Rat CD8α Antibody (OX-8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Rat CD8α Antibody (OX-8) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat CD8α Antibody (OX-8)Transmembrane GlycoproteinCD8αT cellsasthmaRHV-rn1Inhibitorinhibitorinhibit

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