2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse NKG2D/CD314 Antibody (HMG2D)

Anti-Mouse NKG2D/CD314 Antibody (HMG2D) 

Cat. No.: HY-P990804
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Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection.

For research use only. We do not sell to patients.

Anti-Mouse NKG2D/CD314 Antibody (HMG2D)

Anti-Mouse NKG2D/CD314 Antibody (HMG2D) Chemical Structure

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Description

Anti-Mouse NKG2D/CD314 Antibody (HMG2D) is an Armenian hamster-derived IgG antibody inhibitor, targeting to mouse NKG2D/CD314. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can block NKG2D. Anti-Mouse NKG2D/CD314 Antibody (HMG2D) can be used for the researches of cancer, infection, inflammation and immunology, such as B16F10 tumor, colitis and L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infection[1][2][3][4].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

NKG2D/CD314
In Vivo

Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (200 μg, i.p., 3 days after infection and twice weekly thereafter) shows anti-infection effect in L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infected mice[1].
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (250 μg, i.p., twice weekly for 6 weeks) prolongs allograft survival and attenuates cardiac allograft vasculopathy grade companied with anti-CTLA-4 in heart allograft mice[2].
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (150 μg, i.p., twice weekly) hinders the Dacarbazine (HY-B0078) inhibiting effect in tumor growth in B16F10 tumor mice[3].
Anti-Mouse NKG2D/CD314 Antibody (HMG2D) (250 μg, i.p., 3 times weekly for 7 weeks) prevents the development of colitis in CD4+CD45RBhigh T cells transferred SCID mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: L. major parasites and lymphocytic choriomeningitis virus (LCMV) co-infected mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, 3 days after infection and twice weekly thereafter
Result: Completely blocked the increase in ear thickness.
Showed visibly smaller with less ulceration.
Restored control of parasite burden and CD8 T cells.
Led to a partial restoration in monocyte infiltration and completely blocked the excessive infiltration of neutrophils.
Animal Model: Heart allograft mice models[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, twice weekly for 6 weeks, companied with anti-CTLA-4
Result: Prolonged cardiac allograft survival and attenuated cardiac allograft vasculopathy grade.
Attenuated leucocyte infiltration and alloantibody IgM and IgG production.
Inhibited IL-6 expression.
Gene ID

27007  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse NKG2D/CD314 Antibody (HMG2D)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse NKG2D/CD314 Antibody (HMG2D) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse NKG2D/CD314 Antibody (HMG2D)Transmembrane GlycoproteinNKG2DCD314B16F10ColitisL. major parasitesLymphocytic choriomeningitis virusInhibitorinhibitorinhibit

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