2. Cytoskeleton
  3. Integrin
  4. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) 

Cat. No.: HY-P990203 Purity: 95.00%
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Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis.

For research use only. We do not sell to patients.

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Chemical Structure

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Chemical Structure

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1 Publications Citing Use of MCE Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis[1][2][3][4].

Isotype

Rat IgG2a, κ
Recommend Isotype Controls
IC50 & Target

LPAM-1/Integrin α4β7
In Vitro

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (10 μg/mL, 10 mins) blocks the adhesion of FDCP-mix cells to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1)[1].
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (100 μg/mL, 72 h) suppresses the proliferation and cytokine secretion of CD8+ T cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Related Antibodies

Cell Proliferation Assay[1]

Cell Line: CD8+ T cells
Concentration: 100 μg/mL
Incubation Time: 72 h
Result: Suppressed CD8+ proliferation and cytokine IFN-γ secretion
In Vivo

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (2 μg per 106 cells, at least 30 minutes before injecting) reduces homing of HPCs (hematopoietic progenitor cells) to bone marrow in E-selectin–deficient (E-/-) mice models[1].
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (500 μg, i.p., daily from day 8 to 10) does not cause aberrant pregnancies in allogeneic BALB/c x C57BL/6J pregnancies[2].
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (i.p.,a single dose) decreases Peyer’s patches and follicular B cells in C56B6 WT mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Allogeneic BALB/c x C57BL/6J pregnancies mice models[2]
Dosage: 500 μg
Administration: Intraperitoneally injection, daily from day 8 to 10
Result: Blocked recruitment of Mac-1+β7+ monocyte-like cells in vessels.
Showed significantly smaller uNK cells and increased numbers of uNK cells.
Showed histological abnormalities including hypocellularity of the decidua, apoorly organized metrial gland.
Gene ID

16401  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse LPAM-1/Integrin a4b7 Antibody (DATK32)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (233 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32)Integrinα4β7MAdCAM-1CD8T cellsPeyer’s patchesUlcerative colitisInhibitorinhibitorinhibit

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