Anti-Mouse Jagged 2 Antibody (HMJ2-1)

Cat. No.: HY-P990206: Data Sheet
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Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an anti-mouse Jagged 2 IgG monoclonal antibody. Anti-Mouse Jagged 2 Antibody (HMJ2-1) regulates Treg/Th17 balance through IL-9. Anti-Mouse Jagged 2 Antibody (HMJ2-1) increases Jagged2-Notch signaling through activation of RBP-Jk. Anti-Mouse Jagged 2 Antibody (HMJ2-1) can be used for researches on inflammation conditions and xenotransplantation such as experimental autoimmune encephalomyelitis (EAE).

For research use only. We do not sell to patients.

Anti-Mouse Jagged 2 Antibody (HMJ2-1) Chemical Structure

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Anti-Mouse Jagged 2 Antibody (HMJ2-1) Featured Recommendations:

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View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Armenian hamster IgG

Recommend Isotype Controls

Polyclonal Armenian hamster IgG, Isotype Control

Species Reactivity

Mouse

In Vitro

Anti-Mouse Jagged 2 Antibody (HMJ2-1) (20 μg/mL) Slightly enhance osteoclasts derived from mouse bone marrow production, but the effect is not significant^[1].
Anti-Mouse Jagged 2 Antibody (HMJ2-1) (5 μg/mL, 1 h) does not significantly inhibit the expression of GLT-1 induced by endothelial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse Jagged 2 Antibody (HMJ2-1) (250 μg, i.p., once every 2 days for 8 times or once daily for 5 days) can aggravate or alleviate inflammation in female C57BL/6 mice with an MOG_35-55 (HY-P3719) and CFA (HY-153808) induced experimental autoimmune encephalomyelitis (EAE) model^[3].
Anti-Mouse Jagged 2 Antibody (HMJ2-1) (250-500 μg, i.p., on day 0, 2, 4, 6, 8 and 10) has no significant effect on the survival of the transplant in C57BL/6 mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOG_35-55 (50 μg) and CFA (HY-153808) induced female C57BL/6 mice (6-8 weeks)^[3]
Dosage:	250 μg
Administration:	Intraperitoneal injection (i.p.), once every 2 days for 8 times for the preprocessing group or once daily for 5 days for the synchronous treatment group
Result:	Reduced clinical scores and increased Treg/Th17 ratio for the preprocessing group. Increased clinical score and decreased Treg/Th17 ratio for the synchronous treatment group.

Animal Model:	C57BL/6 mice (8-12 weeks)^[4]
Dosage:	500 μg for initial dose, 250 μg for subsequent doses
Administration:	Intraperitoneal injection (i.p.), on day 0, 2, 4, 6, 8 and 10
Result:	Had no significant impact on the survival of heart transplantation.

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse Jagged 2 Antibody (HMJ2-1)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Sekine C, et al. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14(2):R45. [Content Brief]

[2]. Martinez-Lozada Z, et al. Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression. Neurochem Int. 2020 Oct;139:104787. [Content Brief]

[3]. Elyaman W, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity. 2012 Apr 20;36(4):623-34. [Content Brief]

[4]. Riella LV, et al. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun;43(6):1449-58. [Content Brief]

Anti-Mouse Jagged 2 Antibody (HMJ2-1) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Jagged 2 Antibody (HMJ2-1)NotchInterleukin RelatedILJagged 2Treg/Th17EAEInhibitorinhibitorinhibit

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