Anti-Mouse IFNγR/CD119 Antibody (GR-20)

Cat. No.: HY-P990233: Data Sheet
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Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation.

For research use only. We do not sell to patients.

Anti-Mouse IFNγR/CD119 Antibody (GR-20) Chemical Structure

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Purity & Documentation
References
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Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

IFNγR/CD119

In Vitro

Anti-Mouse IFNγR/CD119 Antibody (GR-20) (1 h) reduces non-classical MHC molecule Qa-1^b levels in B16 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse IFNγR/CD119 Antibody (GR-20) (200 μg, i.p., 1 day before infection and then every other day) promotess widespread genital tract inflammation and destruction in C. trachomatis infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C. trachomatis infected mice ^[2]
Dosage:	200 μg
Administration:	Intraperitoneally injection, 1 day before infection and then every other day
Result:	Showed widespread genital tract inflammation and destruction. Increased the frequency of IL-17-producing Chlamydia-specific CD4+ T cells. Dramatically increased the numbers of polymorphonuclear neutrophils and inflammatory monocytes.

Gene ID

15979 [NCBI]

Accession

P15261

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse IFNγR/CD119 Antibody (GR-20)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Montfoort N, et al. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. Cell. 2018 Dec 13;175(7):1744-1755.e15. [Content Brief]

[2]. Vicetti Miguel RD, et al. Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage. PLoS One. 2016 Sep 8;11(9):e0162445. [Content Brief]

Anti-Mouse IFNγR/CD119 Antibody (GR-20) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFNγR/CD119 Antibody (GR-20)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorIFNγCD119C. trachomatisMHCB16MelanomaGenital tract inflammationInhibitorinhibitorinhibit

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