2. Immunology/Inflammation
  3. IFNAR
  4. Anti-Mouse IFN gamma Antibody (XMG1.2)

Anti-Mouse IFN gamma Antibody (XMG1.2) 

Cat. No.: HY-P990798 Purity: 99.00%
COA
SDS
Technical Support

Anti-Mouse IFN gamma Antibody (XMG1.2) is a kind of rat-derived IgG1 antibody inhibitor, targeting to IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can neutralize IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can be used for the researches of cancer, inflammation and immunology, such as multiple myeloma and chronic inflammation.

For research use only. We do not sell to patients.

Anti-Mouse IFN gamma Antibody (XMG1.2)

Anti-Mouse IFN gamma Antibody (XMG1.2) Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse IFN gamma Antibody (XMG1.2) Featured Recommendations:

Anti-Mouse IFN gamma Antibody (XMG1.2) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse IFN gamma Antibody (XMG1.2) is a kind of rat-derived IgG1 antibody inhibitor, targeting to IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can neutralize IFN-γ. Anti-Mouse IFN gamma Antibody (XMG1.2) can be used for the researches of cancer, inflammation and immunology, such as multiple myeloma and chronic inflammation[1][2][3][4][5].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

IFNγ
In Vivo

Anti-Mouse IFN gamma Antibody (XMG1.2) (500 μg, i.p., at days 0, 3, 7, 10, 14, 17) increases multiple myeloma incidence and severity in multiple myeloma mice models[1].
Anti-Mouse IFN gamma Antibody (XMG1.2) is efficacious in a mouse model of hemophagocytic lymphohistiocytosis secondary to chronic inflammation[2].
Anti-Mouse IFN gamma Antibody (XMG1.2) (100 mg/kg, i.v., after 14, 20, 28, 35 and 42 days) improves engraftment in Bacillus Calmette-Guerin-infected Ifngr1-/- mice[3].
Anti-Mouse IFN gamma Antibody (XMG1.2) (100 μg, i.p., every other day from day 10) prevents purkinje cell loss and clinical disease in paraneoplastic cerebellar degeneration mice models[4].
Anti-Mouse IFN gamma Antibody (XMG1.2) (100 µg/g, i.p., a single dose) increases survival rate in LPS (HY-D1056)-induced macrophage activation syndrome mice models[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple myeloma mice models[1]
Dosage: 500 μg
Administration: Intraperitoneally injection, at days 0, 3, 7, 10, 14, 17
Result: Increased serum IgG2b levels and percentages of mice with progressive disease.
Increased BM tumor burden and splenic tumor load.
Animal Model: Paraneoplastic cerebellar degeneration mice models[4]
Dosage: 100 μg
Administration: Intraperitoneally injection, every other day from day 10
Result: Protected mice from the clinical manifestations of paraneoplastic cerebellar degeneration, namely weight loss, and reduced motor performance.
Prevented T cell-mediated Purkinje cell death.
Inhibited T cell accumulation into the cerebellum.
Animal Model: LPS (HY-D1056)-challenged macrophage activation syndrome mice models[5]
Dosage: 100 µg/g
Administration: Intraperitoneally injection
Result: Showed 70% of mice survived treated with 7.5 µg/g LPS, and all mice survived treated with 5 µg/g LPS.
Increased fibrinogen levels and decreased IL-6 and ALT levels.
Gene ID

330496  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IFN gamma Antibody (XMG1.2)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB) SDS-PAGE (63 KB)

Inhibitory Antibodies User Guide (602 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse IFN gamma Antibody (XMG1.2) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFN gamma Antibody (XMG1.2)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorIFN-γCancerInflammationImmunologyMultiple myelomaChronic inflammationPurkinje cellMacrophageInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Mouse IFN gamma Antibody (XMG1.2)
Cat. No.:
HY-P990798
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.