Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8)

Name: Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8)
Brand: MedChemExpress
SKU: HY-P990107
Rating: 4.5 (1 reviews)

Cat. No.: HY-P990107 Purity: ≥95.0%: Data Sheet
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Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) is an TGF-β IgG antibody inhibitor. Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) reduces renal fibrosis in unilateral ureteral obstruction (UUO) mice models. Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) shows potent anti-tumor effect in various tumor models, such as pancreatic cancer. .

For research use only. We do not sell to patients.

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Featured Recommendations:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TGF-β

In Vivo

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) (500 μg, i.v., one day before graftion and three times a week for 5 weeks after graftion) strongly suppresses tumor growth in TC-1 cells grafted mice models^[1].
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) (25 μg/mouse, i.t., at days 4, 7, 11, 14) suppresses tumor growth combined with PD-1 in B16F10E-knockout tumor mice models^[2].
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) (1-10 mg/kg, i.p., daily for 5 days) reduces renal fibrosis in unilateral ureteral obstruction (UUO) mice models^[3].
Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) (200 μg, twice weekly for 21 days) significantly improves overall mortality, weight loss, fat mass, lean body mass, bone mineral density, and skeletal muscle proteolysis in mice harboring advanced pancreatic cancer^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice were grafted with 5 x 10₅ TC-1 cells (C57BL/6, female, 5-6 weeks)^[1]
Dosage:	500 μg
Administration:	Intravenously injection, one day before graftion and three times a week for 5 weeks after graftion
Result:	Strongly reduced the TC-1 tumor growth.

Animal Model:	B16F10E-knockout tumor mice models (C57BL/6, female, 7-9 weeks)^[2]
Dosage:	25 μg/mouse
Administration:	Intra-tumourally injection, at days 4, 7, 11, 14 with 200μg/mouse of anti-PD-1
Result:	Suppressed tumor growth and decreased CD8+ cells.

Animal Model:	Unilateral ureteral obstruction (UUO) mice models (CD1, male, 25-30 g) ^[3]
Dosage:	1, 3, and 10 mg/kg
Administration:	Intraperitoneally injection, daily for 5 days
Result:	Decreased the elevated levels of Col1a1. Induced a dose-related reduction in the binding of the FnEDA mAb. Decreased collagen.

Animal Model:	Endogenous models of advanced murine pancreatic cancer (C57BL/6, female, 6-8 weeks)^[4]
Dosage:	200 μg
Administration:	Twice weekly for 21 days
Result:	Exhibited lower serum levels of TGF-β and lower levels of TGF-β and downstream signaling marker p-SMAD2/3 in skeletal muscle. Improved survival and significantly less weight loss. Had higher fat mass, skinfold thickness, and bone mineral density. Significantly decreased proteolysis. Effectively attenuates pancreatic cancer cachexia with higher rotarod running speed.

Gene ID

21803 [NCBI]

Accession

P04202

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-b Antibody (1D11.16.8)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (233 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Terra M, et al. Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling. Cancer Res. 2018 Jun 1;78(11):3014-3026. [Content Brief]

[2]. Malenica I, et al. Integrin-αV-mediated activation of TGF-β regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade. Nat Commun. 2021 Sep 1;12(1):5209. [Content Brief]

[3]. McGaraughty S, et al. Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach. J Am Soc Nephrol. 2017 Dec;28(12):3616-3626. [Content Brief]

[4]. Greco SH, et al. TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia. PLoS One. 2015 Jul 14;10(7):e0132786. [Content Brief]

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8)TGF-β ReceptorTransforming growth factor beta receptorsTGF-βUnilateral ureteral obstructionPancreatic cancerTumorTC-1 cellsInhibitorinhibitorinhibit

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Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8)

Customer Review

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Featured Recommendations:

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TGF-β Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Anti-Mouse/Human/Rat/Monkey/Hamster/Canine/Bovine TGF-β Antibody (1D11.16.8) Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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