2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD8α Antibody (2.43)

Anti-Mouse CD8α Antibody (2.43) 

Cat. No.: HY-P990790 Purity: 98.78%
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Anti-Mouse CD8α Antibody (2.43) is an anti-mouse CD8α IgG2b monoclonal antibody. Anti-Mouse CD8α Antibody (2.43) can significantly deplete CD8+ T cells. Anti-Mouse CD8α Antibody (2.43) can prolong the survival time of liver cell transplantation. Anti-Mouse CD8α Antibody (2.43) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD8α Antibody (2.43): Rat IgG2b kappa, Isotype Control (HY-P990682).

For research use only. We do not sell to patients.

Anti-Mouse CD8α Antibody (2.43) Chemical Structure

Anti-Mouse CD8α Antibody (2.43) Chemical Structure

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Description

Anti-Mouse CD8α Antibody (2.43) is an anti-mouse CD8α IgG2b monoclonal antibody. Anti-Mouse CD8α Antibody (2.43) can significantly deplete CD8+ T cells. Anti-Mouse CD8α Antibody (2.43) can prolong the survival time of liver cell transplantation. Anti-Mouse CD8α Antibody (2.43) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD8α Antibody (2.43): Rat IgG2b kappa, Isotype Control (HY-P990682)[1][2][3].

Isotype

Rat IgG2b kappa
Recommend Isotype Controls
IC50 & Target

CD8α
In Vivo

Anti-Mouse CD8α Antibody (2.43) (300 μg, i.p., once daily, for 3 days) can effectively deplete CD8a+ cells in female BALB/c mice bearing CT26 tumors[1].
Anti-Mouse CD8α Antibody (2.43) (250 μg, i.p., on the 4th and 2nd day before transplantation) significantly prolongs the survival of liver cell transplants by effectively depleting CD8+ T cells in C57BL/6.SCID mice[2].
Anti-Mouse CD8α Antibody (2.43) (100 μg, i.p., on day -1, 0, 1, 7, 21 and 36) exhausts CD8+ T cells and enhances the severity of arthritis in female BALB/c mice with a Chondroitin sulfate (CS) (HY-B2162)-depleted human fetal aggrecan (HFPG) induced arthritis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (7-8 weeks) bearing CT26 tumors[1]
Dosage: 300 μg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 days
Result: Significantly reduced CD45+CD8a+ cells.
Animal Model: C57BL/6.SCID mice (4-6 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on the 4th and 2nd day before transplantation
Result: Significantly reduced CD8+ T cells.
Extended the survival time of transplants.
Animal Model: CS-depleted HFPG (75 μg) induced female BALB/c mice (6-8 months)[3]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), on day -1, 0, 1, 7, 21 and 36
Result: Caused earlier onset and significantly higher severity of arthritis.
Caused 3 mice to reach the highest score.
Gene ID

12525  [NCBI]

Accession

P01731-1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD8a Antibody (2.43)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD8α Antibody (2.43) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD8α Antibody (2.43)Transmembrane GlycoproteinCD8αT celltransplantimmunologyInhibitorinhibitorinhibit

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