Anti-Mouse CD69 Antibody (CD69.2.2) 

Anti-Mouse CD69 Antibody (CD69.2.2) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD69. Anti-Mouse CD69 Antibody (CD69.2.2) causes CD69 to be internalized but does not deplete CD69⁺ cells. Anti-Mouse CD69 Antibody (CD69.2.2) can be used for the researches of cancer, infection, inflammation and immunology, such as RMA-S tumor, arthritis and vaccinia virus (VACV) infection^[1][2][3].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Mouse

CD69

Anti-Mouse CD69 Antibody (CD69.2.2) (10 μg/mL, 1 h) is readily internalized at 37°C in CD69⁺ cells^[1].
Anti-Mouse CD69 Antibody (CD69.2.2) (10 μg/mL, 18 h) increases cytotoxicity of NK cells in splenocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg, i.p., at days -1 or 1) results that more than 80% of the mice remained alive and tumor free after 8 weeks in RMA-S tumor mice models^[1].
Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg, i.p., at days 1 and 5) reduces tumor metastasis and prolongs survival in RM-1 tumor mice models^[1].
Anti-Mouse CD69 Antibody (CD69.2.2) (200 μg, i.p., a single dose) consistently and significantly increases NK-dependent cytotoxic activity in RMA-S/RM-1/YAC-1 tumor mice models^[1].
Anti-Mouse CD69 Antibody (CD69.2.2) (300 μg, i.p., at days 1 and 5) downregulates CD 69 expression and does not affect disease severity in collagen antibody-induced arthritis mice models^[2].
Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg, i.v., 24 h before infection) enhances the innate immune response in vaccinia virus (VACV)-infected mice models^[3].
Anti-Mouse CD69 Antibody (CD69.2.2) (200 μg, i.v., twice a week) shows anti-infection in vaccinia virus (VACV)-infected Rag2^-/- mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12515  [NCBI]

P37217

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse CD69 Antibody (CD69.2.2)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Esplugues E, et al. Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood. 2005 Jun 1;105(11):4399-406.  [Content Brief]

  [2]. Lamana A, et al. The role of CD69 in acute neutrophil-mediated inflammation. Eur J Immunol. 2006 Oct;36(10):2632-8.  [Content Brief]

  [3]. Notario L, et al. CD69 Targeting Enhances Anti-vaccinia Virus Immunity. J Virol. 2019 Sep 12;93(19):e00553-19.  [Content Brief]