Anti-Mouse CD317/BST2 Antibody (927) 

Anti-Mouse CD317/BST2 Antibody (927) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse CD317/BST2. Anti-Mouse CD317/BST2 Antibody (927) can deplete plasmacytoid dendritic cells (pDC). Anti-Mouse CD317/BST2 Antibody (927) can be used for the researches of cancer, infection, inflammation and immunology, such as head and neck squamous cell carcinoma (HNSCC), murine cytomegalovirus (MCMV) infection and asthma^[1][2][3][4].

Rat IgG2b kappa

Rat IgG2b kappa, Isotype Control

Mouse

CD317/BST2

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD317/BST2 Antibody (927) (250 μg, i.p., 48 and 24 h prior to infection) reduces the plasmacytoid dendritic cells (pDC) population and serum IFNα levels in murine cytomegalovirus (MCMV)-infected mice models^[1].
Anti-Mouse CD317/BST2 Antibody (927) (15 mg/kg, i.p., every other day) effectively depletes plasmacytoid dendritic cells (pDC) and inhibits tumor growth in head and neck squamous cell carcinoma (HNSCC) mice models^[2].
Anti-Mouse CD317/BST2 Antibody (927) (50 μg, i.v., twice a week for 5 weeks from 1 h before HDM) reduces plasmacytoid dendritic cells (pDC) and promotes inflammation responses in house dust mite (HDM)-induced asthma mice models^[3].
Anti-Mouse CD317/BST2 Antibody (927) (250 μg, i.p., at days7 and 8) ameliorates EAE and shortens disease duration in experimental autoimmune encephalomyelitis (EAE) mice models^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

69550  [NCBI]

Q8R2Q8

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD317/BST2 Antibody (927)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nash WT, et al. Murine Cytomegalovirus Disrupts Splenic Dendritic Cell Subsets via Type I Interferon-Dependent and -Independent Mechanisms. Front Immunol. 2017 Mar 9;8:251.  [Content Brief]

  [2]. Yang LL, et al. pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma. Oral Oncol. 2019 Sep;96:131-139.  [Content Brief]

  [3]. Park SY, et al. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013 Apr 1;190(7):3480-92.  [Content Brief]

  [4]. Manouchehri N, et al. CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2014492118.  [Content Brief]