Anti-Mouse CD22 Antibody (Cy34.1) 

Anti-Mouse CD22 Antibody (Cy34.1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD22. Anti-Mouse CD22 Antibody (Cy34.1) can deplete CD22 cells and B cells. Anti-Mouse CD22 Antibody (Cy34.1) can promote microglial phagocytosis. Anti-Mouse CD22 Antibody (Cy34.1) can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease (AD) and neuromyelitis^[1][2][3].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Mouse

CD22

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD22 Antibody (Cy34.1) (150 μg, i.p., a single dose) depletes B cells in combination with anti-CD19 (HY-P99976) and anti-rat κ Light Chain (HY-P990120) in mice^[1].
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL, intracerebrally injection, a single dose) promotes clearance of myelin debris in aged mouse^[2].
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL, intracerebrally injection, a single dose) clears injected Aβ oligomers and extracellular α-synuclein fibrils in Aβ-injected aged mouse^[2].
Anti-Mouse CD22 Antibody (Cy34.1) (100 μg/mouse, intrastriatally injection, a single dose) depletes CD22-expressing cells and exacerbates NMOSD pathology in neuromyelitis optica spectrum disorder (NMOSD) mice^[3].
Anti-Mouse CD22 Antibody (Cy34.1) (10 mg/kg, i.v., three days prior to NMOSD induction) depletes B cells in NMOSD mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12483  [NCBI]

P35329-1

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse CD22 Antibody (Cy34.1)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Säwén P, et al. Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Cell Rep. 2016 Mar 29;14(12):2809-18.  [Content Brief]

  [2]. Pluvinage JV, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019 Apr;568(7751):187-192.  [Content Brief]

  [3]. Zhang W, et al. CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder. J Neuroinflammation. 2024 Nov 30;21(1):313.  [Content Brief]