2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD172a Antibody (P84)

Anti-Mouse CD172a Antibody (P84) 

Cat. No.: HY-P990289 Purity: 95.00%
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Anti-Mouse CD172a Antibody (P84) is a rat-derived anti-mouse CD172a IgG1 κ type antibody inhibitor. Anti-Mouse CD172a Antibody (P84) blocks CD47-SIRPα interaction and thereby augments cell phagocytosis. Anti-Mouse CD172a Antibody (P84) can be used for the researches of infection and immunology, such as salmonella typhimurium infection.

For research use only. We do not sell to patients.

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Description

Anti-Mouse CD172a Antibody (P84) is a rat-derived anti-mouse CD172a IgG1 κ type antibody inhibitor. Anti-Mouse CD172a Antibody (P84) blocks CD47-SIRPα interaction and thereby augments cell phagocytosis. Anti-Mouse CD172a Antibody (P84) can be used for the researches of infection and immunology, such as salmonella typhimurium infection[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
IC50 & Target

CD172a
In Vitro

Anti-Mouse CD172a Antibody (P84) (20 mins) significantly increases the engulfment of WT mouse RBCs[1].
Anti-Mouse CD172a Antibody (P84) (5 μg/mL, 30 mins) enhances the phagocytic incorporation of salmonella typhimurium into Nr2f6-deficient macrophages in splenocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD172a Antibody (P84) Related Antibodies
In Vivo

Anti-Mouse CD172a Antibody (P84) (100 μg, i.p., one day prior to infection and at days 1 and 2 post-infection) results in weight loss and bacterial counts increase in Nr2f6-deficient mice infected by salmonella typhimurium[2].
Anti-Mouse CD172a Antibody (P84) (i.p., 24 h before cells injection) prevents the effects of mouse CD47 on macrophage-mediated xenograft rejection in diabetic Rag22/2 c chain 2/2 mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Salmonella typhimurium infectious mice models (Nr2f6-deficient mice)[2]
Dosage: 100 μg
Administration: Intraperitoneally injection, one day prior to infection and at days 1 and 2 post-infection
Result: Showed body weight loss.
Increased splenic and liver bacterial counts.
Increased CD172a-positive cells and abolished Sirp𝛼 (CD172a)-positive CD45+ blood cells.
Animal Model: The diabetic Rag22/2 c chain 2/2 mice were injected by mCD47-INS-1E or cont-INS-1E cells or CFSE-labeled congenic T cells[3]
Dosage: /
Administration: Intraperitoneally injection, 24 h before cells injection
Result: Failed to achieve normoglycemia.
Did not induce phagocytosis of congenic cells.
Gene ID

19261  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD172a Antibody (P84)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized SIRP alpha/CD172a Protein, Mouse (HEK293, His, HY-P72468) can bind Anti-Mouse CD172a Antibody (P84). The EC50 for this effect is 99.62 ng/mL.
Purity & Documentation
References
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Anti-Mouse CD172a Antibody (P84) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD172a Antibody (P84)Transmembrane GlycoproteinCD172aSIRPαCD47PhagocytosisInfectionSalmonella typhimuriumInhibitorinhibitorinhibit

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