Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) is a rat-derived IgG2b λ type antibody inhibitor, targeting to mouse CCR3/CD193. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can deplete eosinophils. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can be used for the researches of cancer, infection, inflammation and immunology, such as lymphoma, ileitis and strongyloides stercoralis infection^[1][2][3][4].

Rat IgG2b

Rat IgG2b kappa, Isotype Control

Mouse

CCR3/CD193

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (350 μg i.p. at 1 day before infection and 2 days after infection, and 100 μg s.c. in the vicinity of the implanted diffusion chamber) depletes eosinophils and increases larval survival in L3 of strongyloides stercoralis infected mice^[1].
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (200 μg i.p. once a week from 20 to 30 weeks of age) depletes eosinophils and attenuates ileitis in chronic ileitis mice ^[2].
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (100 μg i.p. at days 13 and 15) impedes anti-CD19 chimeric antigen receptor T cell antitumor efficacy in A20 lymphoma mice^[3].
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (1 mg i.p. 1 day before IL-5 injection) abolishes eotaxin-2-induced airway hyperreactivity and inhibits IL-13 production in BALB/c wild-type mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12711  [NCBI]

P51678

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Galioto AM, et al. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun. 2006 Oct;74(10):5730-8.  [Content Brief]

  [2]. Masterson JC, et al. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Am J Pathol. 2011 Nov;179(5):2302-14.  [Content Brief]

  [3]. Jia Q, et al. Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma. Theranostics. 2021 Mar 4;11(10):4699-4709.  [Content Brief]

  [4]. Yang M, et al. Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. J Allergy Clin Immunol. 2003 Nov;112(5):935-43.  [Content Brief]