AN11736 

AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC₅₀s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models^[1][2].

AN11736 exhibits excellent metabolic stability in mouse and bovine liver S9^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AN11736 (10 mg/kg, i.p. (mice) and i.m (cattle), single dose) demonstrates 100% efficacy with a single dose of 10 mg/kg against both T. congolense and T. vivax in mouse and cattle models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

399.22

C₂₁H₂₃BFNO₅

2152662-85-4

OB1OCC2=CC=C(C(N[C@@H](C(C)C)C(OCC3=CC=C(F)C=C3)=O)=O)C(C)=C21

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Akama T, et al. Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10.  [Content Brief]

  [2]. Wall RJ, et al. Clinical and veterinary trypanocidal benzoxaboroles target CPSF3. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621.  [Content Brief]