2. Immunology/Inflammation TGF-beta/Smad Stem Cell/Wnt
  3. CTLA-4 TGF-beta/Smad
  4. AN02

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.

For research use only. We do not sell to patients.

AN02

AN02 Chemical Structure

CAS No. : 1246964-08-8

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Description

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer[1].

Molecular Weight

344.23

Formula

C19H15Cl2NO
CAS No.
SMILES

ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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AN02 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AN021246964-08-8AN 02AN-02CTLA-4TGF-beta/SmadCytotoxic T-lymphocyte-associated protein 4CD152Transforming growth factor betacurcumin derivativeovarian cancerAPC-SMAD4-CTLA-4 axisproliferation inhibitionubiquitinationimmune checkpointEMTxenograft modelInhibitorinhibitorinhibit

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