2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. AMG-34

AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively.

For research use only. We do not sell to patients.

AMG-34

AMG-34 Chemical Structure

CAS No. : 1644664-11-8

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AMG-34 Related Antibodies

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Description

AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively[1].

In Vitro

AMG-34 (0–10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, causing the most significant decrease in cell viability at intermediate concentrations (around 0.1 μM), while showing reduced inhibitory effects at both lower and higher concentrations[1].
AMG-34 (0.01-0.37 μM, 8 h) increases the expression of ATF4 in MOLM-16 cells[1].
AMG-34 (1.1-10 μM, 8 h) inhibits the expression of p-GCN2 while shows no effect on the expression of GCN2 in MOLM-16 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMG-34 Related Antibodies
Molecular Weight

558.60

Formula

C33H27FN6O2
CAS No.
SMILES

CN(N(C1=CC=CC=C1)C2=O)C(C3=CC=CC=C3)=C2C(C4=CC=C(C)C(C5=C(F)C6=CN=C(NC)N=C6C=C5)=C4N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMG-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-341644664-11-8AMG34AMG 34Eukaryotic Initiation Factor (eIF)MOLM-16 cellsInhibitorinhibitorinhibit

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