2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine receptor antagonist 7

Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with Ki values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC50 = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

Adenosine receptor antagonist 7

Adenosine receptor antagonist 7 Chemical Structure

CAS No. : 2570904-69-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Adenosine receptor antagonist 7 Related Antibodies

Top Publications Citing Use of Products

View All Adenosine Receptor Isoform Specific Products:

View All Isoforms
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with Ki values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC50 = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer[1].

IC50 & Target[1]

A1

1.5 nM (Ki)

A2A

0.6 nM (Ki)

A2B

21 nM (Ki)

In Vitro

Adenosine receptor antagonist 7 (Compound 14a) (0.32-1000 nM, 30 mins) inhibits NECA (HY-103173)-induced cAMP accumulation in human CD8+T cells (IC50 = 18 nM)[1].
Adenosine receptor antagonist 7 (10-100 nM, 30 mins) inhibits the phosphorylation of ERK and JNK, downregulates the mRNA expression of MMP-2 and MMP-9 in A1R-overexpressing SK-BR-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adenosine receptor antagonist 7 Related Antibodies

Western Blot Analysis[1]

Cell Line: A1R-overexpressing SK-BR-3 cells
Concentration: 10 and 100 nM
Incubation Time: 30 mins
Result: Reduced the phosphorylation of ERK and JNK.
In Vivo

Adenosine receptor antagonist 7 (Compound 14a) (50 mg/kg, p.o., twice a day for 14 days) inhibits tumor growth in BALB/c nude mice bearing CT26 tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice bearing CT26 tumors[1]
Dosage: 50 mg/kg
Administration: Orally administration, twice a day for 14 days
Result: Inhibited tumor growth without adverse reactions such as weight loss.
Increased the number of tumor-infiltrating effector T cells and improved the CD8+/Treg ratio when combined with Avelumab.
Molecular Weight

390.44

Formula

C21H22N6O2
CAS No.
SMILES

NC1=NC(N2C=CN=C2)=C(C(C3=CC(N4CC[C@H](C4)OC)=CC(OC)=C3)=C1)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Adenosine receptor antagonist 7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine receptor antagonist 72570904-69-5Adenosine receptor antagonist7Adenosine receptor antagonist-7Adenosine ReceptorP1 receptorNECAERKJNKMMP-2MMP-9CT26Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Adenosine receptor antagonist 7
Cat. No.:
HY-179248
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.