2. Membrane Transporter/Ion Channel
  3. BCRP
  4. Ac22(Az8)2

Ac22(Az8)2​ is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers.

For research use only. We do not sell to patients.

Ac22(Az8)2

Ac22(Az8)2 Chemical Structure

CAS No. : 2377858-65-4

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Ac22(Az8)2 Related Antibodies

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Description

Ac22(Az8)2​ is a selective BCRP inhibitor (EC50: 1-2 nM). Ac22(Az8)2 can restore the drug sensitivity of BCRP-overexpressing cells by inhibiting BCRP-ATPase activity, blocking drug efflux, and increasing intracellular drug accumulation. Ac22(Az8)2 can be used in the research of BCRP-mediated multidrug-resistant cancers[1].

Molecular Weight

1157.18

Formula

C66H56N6O14
CAS No.
SMILES

O=C(C(OCC1=CC=CC(C(OC)=O)=C1)=C(C2=CC=C(OCCOCCN3N=NC(C4=CC(C5=CN(CCOCCOC6=CC=C(C7=C(OCC8=CC(C(OC)=O)=CC=C8)C(C(C=CC=C9)=C9O7)=O)C=C6)N=N5)=CC=C4)=C3)C=C2)O%10)C%11=C%10C=CC=C%11
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Ac22(Az8)2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac22(Az8)22377858-65-4BCRPBreast cancer resistance proteinABCG2HEK293/R2cancerInhibitorinhibitorinhibit

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