2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. AB19

AB19 is a potent Vav1 inhibitor. AB19 inhibits Vav1 and reduces its downstream ERK phosphorylation. AB19 shows anti-proliferative activity in pancreatic cancer models. AB19 can be used for pancreatic cancer research.

For research use only. We do not sell to patients.

AB19

AB19 Chemical Structure

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AB19 Related Antibodies

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Description

AB19 is a potent Vav1 inhibitor. AB19 inhibits Vav1 and reduces its downstream ERK phosphorylation. AB19 shows anti-proliferative activity in pancreatic cancer models. AB19 can be used for pancreatic cancer research[1].

In Vitro

AB19 (0-1 μM, 4 days) exhibits antitumoral activity in Vav1 positive pancreatic cancer lines, including CAPAN-2, MIA PaCa-2, and CFPAC cells[1].
AB19 (0.1-1 μM) reduces Vav1 expression and inhibits ERK phosphorylation in CAPAN-2 cells[1].
AB19 (0-1 μM, 5 days) exhibits antitumoral activity in pancreatic cancer patient-derived organoids (PDOs), showing greater potency in Vav1 high-expressing HO219 compared to the low-expressing HO163 model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB19 Related Antibodies

Cell Viability Assay[1]

Cell Line: CAPAN-2, MIA PaCa-2, CFPAC, ASPC-1, and HPNE cells
Concentration: 0, 0.1, and 1 μM
Incubation Time: 4 days
Result: Showed a reduction in Vav1 positive cell (CAPAN-2, MIA PaCa-2, and CFPAC) numbers relative to the control at 1 μM.
Showed no effect on Vav1 negative ASPC-1 and HPNE cells.
Molecular Weight

540.57

Formula

C28H46BrNO4
SMILES

CCCCCCCCCCCCCC[N+]1=CC=C(OCC(C/C2=C(C)\C)(CO)OC2=O)C=C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB19AB 19AB-19ERKExtracellular signal regulated kinasesVav1pancreaticCAPAN-2MIA PaCa-2CFPACPDOsHO219HO163Inhibitorinhibitorinhibit

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