2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. A-620223

A-620223 is a PARP-1 inhibitor with a Ki of 8 nM against PARP-1 and EC50 of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) (HY-17364) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer.

For research use only. We do not sell to patients.

A-620223

A-620223 Chemical Structure

CAS No. : 272769-49-0

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Based on 1 publication(s) in Google Scholar

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Description

A-620223 is a PARP-1 inhibitor with a Ki of 8 nM against PARP-1 and EC50 of 3 nM in a whole cell assay. A-620223 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with Temozolomide (TMZ) (HY-17364) and in an MX-1 breast xenograph model in combination with Cisplatin (HY-17394). A-620223 can be used for the studies of melanoma and breast cancer[1].

IC50 & Target[1]

PARP-1

8 nM (Ki)

In Vivo

A-620223 (1-25 mg/kg, s.c., successive administration for 7-14 days) demonstrates excellent potentiation of two cytotoxic agents, Temozolomide and Cisplatin, in both a mouse melanoma and a breast cancer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 melanoma model and MX-1 breast cancer xenograft model established in C57BL/6 mice and female SCID mice[1]
Dosage: 1, 12.5 and 25 mg/kg (melanoma model); 5 and 25 mg/kg (breast cancer model)
Administration: Subcutaneous injection (s.c.), successive administration for 7-14 days
Result: Showed excellent potentiation of cytotoxic agents in two subcutaneous, murine tumor models.
Molecular Weight

286.37

Formula

C16H22N4O
CAS No.
Appearance

Solid

SMILES

CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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A-620223 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-620223272769-49-0A620223A 620223PARPpoly ADP ribose polymerasePoly(ADP-ribose)polymerasePARP inhibitorBenzimidazole carboxamideInhibitorinhibitorinhibit

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