2. Signaling Pathways
  3. Epigenetics
  4. WDR5

WDR5

WD repeat protein-5; WD40 repeat domain protein 5

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes. WDR5 also plays a crucial role in mediating protein-protein interactions that sustain oncogenesis in human cancers. One prominent example is the interaction between the transcription factor MYC and WDR5, which is essential for oncogenic processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-148817
    WDR5-0102
    		Inhibitor
    WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.
    WDR5-0102
  • HY-162014
    WDR5 degrader-1
    		Degrader 98.00%
    WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1.
    WDR5 degrader-1
  • HY-100869
    MM-589
    		Inhibitor
    MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
    MM-589
  • HY-132233
    DDO-2093
    		Inhibitor
    DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex.
    DDO-2093
  • HY-141797
    MS33
    		Degrader
    MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia.
    MS33
  • HY-100869B
    MM-589 (racemic mixture ) TFA
    		Inhibitor 99.83%
    MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
    MM-589 (racemic mixture ) TFA
  • HY-141798
    OICR-9429-N-C2-NH2
    		Ligand
    OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs.
    OICR-9429-N-C2-NH2
  • HY-150403
    XF067-68
    		Degrader 99.56%
    XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) (extracted from patent WO2019246570A1).
    XF067-68
  • HY-157332
    WDR5-IN-7
    		Inhibitor
    WDR5-IN-7 (Compound 22) is an orally bioavailable benzoxazepinone-based WD repeat domain 5 (WDR5) inhibitor. WDR5-IN-7 can be used for the research of anti-cancer.
    WDR5-IN-7
  • HY-RS15789
    WDR5B Human Pre-designed siRNA Set A
    		Degrader

    WDR5B Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    WDR5B Human Pre-designed siRNA Set A
    WDR5B Human Pre-designed siRNA Set A
  • HY-RS15785
    WDR5 Human Pre-designed siRNA Set A
    		Degrader

    WDR5 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    WDR5 Human Pre-designed siRNA Set A
    WDR5 Human Pre-designed siRNA Set A
  • HY-159993
    MR44397
    		Inhibitor
    MR44397 is a WD40 repeat (WDR) 5 ligand, can be used for cancer research.
    MR44397
  • HY-172196
    LH168
    LH168 is a potent and selective chemical probe for WDR5, with a SPR Kd value of 13 nM.
    LH168
  • HY-153331
    DDO-2213
    		Inhibitor
    DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.
    DDO-2213
  • HY-150400
    XF056-132 free base
    		Degrader
    XF056-132 free base is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader.
    XF056-132 free base
  • HY-161123
    WDR5-IN-8
    		Inhibitor
    WDR5-IN-8 is a WDR5 inhibitor with IC50 value of 15.5 nM. WDR5-IN-8 shows good anti-proliferative activity in two human acute leukemia cell lines. WDR5-IN-8 has antitumor activity.
    WDR5-IN-8
  • HY-P10948
    CS-VIP 8
    		Inhibitor
    CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (Ki= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia.
    CS-VIP 8
  • HY-168475
    DD0-2363
    		Inhibitor
    DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. DD0-2363 inhibits cells proliferation and induces apoptosis in acute myeloid leukemia cells. DD0-2363 has antitumor activity and can be used in the research of acute myeloid leukemia.
    DD0-2363
  • HY-150400A
    XF056-132
    		Degrader
    XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).
    XF056-132
  • HY-168487
    PROTAC WDR5 degrader 1
    		Inhibitor
    PROTAC WDR5 degrader 1 (compound 8g) is a PROTAC degrader targeting WDR5. PROTAC WDR5 degrader 1 is composed of a target protein ligand (red part) WDR5 ligand 2 (HY-168488), a VHL-type E3 ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and a PROTAC linker (balck part) 5-Aminovaleric acid (HY-W015878), in which the VHL ligand and the PROTAC linker form a conjugate (HY-114176A).
    PROTAC WDR5 degrader 1
Cat. No. Product Name / Synonyms Application Reactivity