2. Epigenetics
  3. WDR5
  4. DDO-2213

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.

For research use only. We do not sell to patients.

DDO-2213

DDO-2213 Chemical Structure

CAS No. : 2378768-36-4

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

DDO-2213 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].

Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
K562 IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MOLM-13 GI50
13.09 μM
Compound: DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MOLM-13 IC50
13.1 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MV4-11 GI50
12.57 μM
Compound: DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MV4-11 IC50
12.6 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
Molecular Weight

483.97

Formula

C24H27ClFN7O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC(NC3=NC=NC(Cl)=C3N)=C(N4CCN(C)CC4)C=C2F)C=C1)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (258.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0662 mL 10.3312 mL 20.6624 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0662 mL 10.3312 mL 20.6624 mL 51.6561 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL 10.3312 mL
10 mM 0.2066 mL 1.0331 mL 2.0662 mL 5.1656 mL
15 mM 0.1377 mL 0.6887 mL 1.3775 mL 3.4437 mL
20 mM 0.1033 mL 0.5166 mL 1.0331 mL 2.5828 mL
25 mM 0.0826 mL 0.4132 mL 0.8265 mL 2.0662 mL
30 mM 0.0689 mL 0.3444 mL 0.6887 mL 1.7219 mL
40 mM 0.0517 mL 0.2583 mL 0.5166 mL 1.2914 mL
50 mM 0.0413 mL 0.2066 mL 0.4132 mL 1.0331 mL
60 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8609 mL
80 mM 0.0258 mL 0.1291 mL 0.2583 mL 0.6457 mL
100 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5166 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DDO-2213 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-22132378768-36-4DDO2213DDO 2213WDR5WD repeat protein-5WD40 repeat domain protein 5MLL Fusion LeukemiaWD repeat-containing protein 5MV4-11 tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DDO-2213
Cat. No.:
HY-153331
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.