Virus Protease

Related Products

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Virus Protease Related Products (304)
Antibodies (1)

By Effects:	Control (1) Inhibitors (275) Degraders (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-176264

DNDI-6510	Inhibitor
DNDI-6510 (Compound (S)-x38) is a non-covalent SARS-CoV-2 MPro inhibitor with a IC₅₀ of 0.04 μM. DNDI-6510 has a potent antiviral activity across SARS-CoV-2 and its variants as well as a weak efficacy to SARS-CoV-1. DNDI-6510 significantly improves drug exposure in metabolically humanized mice model (8HUM).

HY-N0470S2

L-Lysine-¹³C dihydrochloride	Inhibitor	99.90%
L-Lysine-¹³C (dihydrochloride) is the ¹³C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-152083

DENV-IN-9	Inhibitor
DENV-IN-9 (Compound 5f) is a DENV2 inhibitor with an EC₅₀ of 0.88 μM.

HY-G0021S

N-Desmethylclozapine-d₈	Inhibitor
N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.

HY-170598

HP211206	Inhibitor
HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity. (Pink: H117 (HY-170599); Black: linker (HY-B0236); Blue: E3 ligase ligand (HY-41547)).

HY-161245

FGA146	Inhibitor
FGA146 is a dual, selective inhibitor for M^pro and human Cathepsin L, with K_is of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-M^pro, pET21-M^pro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.

HY-151589

HCVcc-IN-2	Inhibitor
HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498).

HY-148167

2'-Deoxy-2'-fluoro-l-uridine	Inhibitor
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication.

HY-136573

5-Hydroxytoluene-2,4-disulphonic acid diammonium	Inhibitor
5-Hydroxytoluene-2,4-disulphonic acid diammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.

HY-138958

HT1171	Inhibitor
HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC₉₀ of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent.

HY-W705873

Edoxudine-d₅
Edoxudine-d₅ (EUDR-d₅) is the deuterium labeled Edoxudine (HY-B1011). Edoxudine is an antiviral active molecule and thymidine analog. Edoxudine is effective against herpes simplex virus.

HY-156734

D-4-77	Inhibitor
D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC₅₀ value of 0.95 μM. D-4-77 has antiviral active with an EC₅₀ value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response.

HY-N0017R

Bergenin (Standard)	Inhibitor
Bergenin (Standard) is the analytical standard of Bergenin. This product is intended for research and analytical applications. Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties.

HY-E70610

SARS-CoV-2 main protease
SARS-CoV-2 main protease is a main protease (Mpro) of SARS-CoV-2, which plays a central role in viral replication and transcription and represents an attractive drug target for fighting COVID-19.

HY-162474

BZG2	Inhibitor
BZG2 is an allosteric inhibitor for the SARS-CoV-2 main protease (M^pro), with an IC₅₀ of 77 µM.

HY-170357

SARS-CoV-2 3CLpro-IN-28	Inhibitor
SARS-CoV-2 3CLpro-IN-28 (Compound 19) is an inhibitor for SARS-CoV-2 3CLpro with an IC₅₀ of 0.018 μM.

HY-G0021S1

N-Desmethylclozapine-d₈ hydrochloride	Inhibitor	99.74%
N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist.

HY-162790

SARS-CoV-2-IN-95	Inhibitor
SARS-CoV-2-IN-95 (Compound 10) is an inhibitor for SARS-CoV-2 PLpro with an IC₅₀ of 0.39 μM. SARS-CoV-2-IN-95 exhibits antiviral activity in mouse SARS-CoV-2-infected model.

HY-B1290S1

2-Phenylethanol-d₉
2-Phenylethanol-d₉ is the deuterium labeled 2-Phenylethanol. 2-Phenylethanol (Phenethyl alcohol), extracted from rose, carnation, hyacinth, Aleppo pine, orange blossom and other organisms, is a colourless liquid. It has a pleasant floral odor and also an autoantibiotic produced by the fungus Candida albicans. It is used as an additive in cigarettes and also used as a preservative in soaps due to its stability in basic conditions.

HY-161789

PROTAC SARS-CoV-2 Mpro degrader-3	Inhibitor
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC₅₀=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC₅₀ of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .

Name
Email *

	Sorry, but the email address you supplied was invalid.

Virus Protease

Virus Protease

Virus Protease Related Products (304)

Antibodies (1)

Virus Protease Related Products (304):