Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein Related Products (252):

By Effects:	Inhibitors (175) Ligands (6) Agonists (3) Antagonists (5) Activators (8) Modulators (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P991109

Anti-EFNA4 Antibody	Inhibitor
Anti-EFNA4 Antibody (PF-06647263 antibody) is a human antibody expressed in CHO cells, targeting EFNA4. Anti-EFNA4 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991172

JNJ-70218902
JNJ-70218902 is a bispecific antibody that binds to human TMEFF2 on cancer cells and to human CD3 on T cells. JNJ-70218902 induces an exposure-dependent proinflammatory response and targeted tumor cell lysis, and promotes T cell-mediated tumor cell killing (EC₅₀: 1.4 nM). JNJ-70218902 has a promising potential for prostate cancer research. The recommended isotype control is human IgG4 kappa, isotype control (HY-P99003).

HY-P990357

Anti-CD69 Antibody	Inhibitor
Anti-CD69 Antibody is a human-derived antibody expressed in CHO, targeting CD69. The predicted molecular weight (MW) of Anti-CD69 Antibody is 150 kDa. The isotype control for Anti-CD69 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991368

BSI-046	Inhibitor
BSI-046 is a human monoclonal antibody (mAb) targeting SLAMF7/CS1. BSI-046 can be used in Multiple Myeloma research.

HY-P10183

CD36 Peptide P (139-155), Cys conjugated	Inhibitor
CD36 Peptide P (139-155), Cys conjugated is a Cys labelled CD36 Peptide, and can inhibit the immunoadsorption of CD36 by OKM5.

HY-P5472

Tumour-associated MUC1 epitope
Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)

HY-E70190

Tyrosylprotein Sulfotransferase 2	Activator
Tyrosylprotein Sulfotransferase 2 (TPST-2) is a subtype of TPST. Tyrosylprotein Sulfotransferase is a 54- to 50-kDa integral membrane glycoprotein of the trans-Golgi network found in essentially all tissues investigated, catalyzing the tyrosine O-sulfation of soluble and membrane proteins passing through this compartment.

HY-P11127

MBP (111-129)
MBP (111-129) is a polypeptide that constitutes an immunodominant epitope cluster restricted by HLA-DRB10401. MBP (111-129) is an antagonist for the clone HD4-1C2 TCR* and an agonist for clone MS2-3C8 TCR. MBP (111-129) can be used for on multiple sclerosis and T cell biology.

HY-P1924A

IRBP(651-670) human, mouse TFA
IRBP(651-670) human, mouse (TFA) represents the amino acid sequence from positions 651 to 670 of the interphotoreceptor retinoid binding protein (IRBP). IRBP(651-670) human, mouse (TFA) can be used to induce experimental autoimmune uveitis.

HY-P991305

AGEN-1571
AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)

HY-P991575

AT003
AT003 is a humanized monoclonal antibody targeting EpCAM/TROP1/CD326. AT003 can be used for synthesis of ADC.

HY-P990235

Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3)	Inhibitor
Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) contains the D265A mutation region. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can be used for researches of inflammation and infection.

HY-164311

GPR17 modulator-1	Modulator
GPR17 modulator-1 (Compound 2-046) is a modulator for G protein-coupled receptor 17 GPR17, with an IC₅₀<10 nM for hGPR17 in CHO. GPR17 modulator-1 exhibits moderate pharmacokinetic characteristics in mice. GPR17 modulator-1 ix blood-brain barrier (BBB) permeable.

HY-P990843

Anti-Glycophorin A (type M) Antibody (6A7M)
Anti-Glycophorin A (type M) Antibody (6A7M) is a kind of mouse IgG1, κ chimeric antibody, targeting to human Glycophorin A (type M). The recommend isotype control of Anti-Glycophorin A (type M) Antibody (6A7M): Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-P1822A

BDC2.5 mimotope 1040-31 TFA	Inhibitor
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg⁺T cells.

HY-P991470

Anti-Tenascin C Antibody	Inhibitor
Anti-Tenascin C Antibody (Neuradiab antibody) is a human monoclonal antibody (mAb) targeting Tenascin C. Anti-Tenascin C Antibody can be used in Glioblastoma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991618

ST2485	Inhibitor
ST2485 is a monoclonal antitenascin antibody. ST2485 shows additivity in tenascin C binding in vitro as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research.

HY-P991643

MTRX1011A	Inhibitor
MTRX1011A is a humanized IgG1 monoclonal antibody inhibitor targeting CD4. MTRX1011A can be used for rheumatoid arthritis (RA) research.

HY-P990262

Anti-Mouse CD8 Antibody (HB-129)	Inhibitor
Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8⁺ T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD).

HY-P991111

Anti-Mouse TIGIT Antibody (10A7)	Inhibitor
Anti-Mouse TIGIT Antibody (10A7) is a mouse IgG2 monoclonal antibody that targets TIGIT. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).

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