2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. SOS1

SOS1

Ras/Rac guanine nucleotide exchange factor 1

 

SOS1 Related Products (61):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132129
    SOS1-IN-2
    		Inhibitor
    SOS1-IN-2 (Compound 1-1) is an inhibitor of SOS1 with an IC50 value of 5 nM. SOS1-IN-2 can be used in tumor research.
    SOS1-IN-2
  • HY-145048
    SOS1-IN-5
    		Inhibitor
    SOS1-IN-5 is a potent inhibitor of SOS1. SOS1-IN-5 is a pyrimidobicyclic derivative. SOS1-IN-5 blocks the activation of KRAS by interfering with RAS-SOS1 interaction, and achieves the purpose of broad-spectrum inhibition of KRAS activity. SOS1-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2021203768A1, compound 4).
    SOS1-IN-5
  • HY-153940
    SOS1/KRAS-IN-1
    		Inhibitor
    SOS1/KRAS-IN-1(Compound 2) is a SOS1/KRAS inhibitor, which can be used in the research of SOS1/KRAS-mediated diseases.
    SOS1/KRAS-IN-1
  • HY-168514
    SOS1/EGFR-IN-2
    		Inhibitor
    SOS1/EGFR-IN-2 (Compound 4) is a SOS1 and EGFR dual inhibitor with IC50s of 8.3 and 14.6 nM, respectively. SOS1/EGFR-IN-2 exhibits significant antiproliferative effect on the cancer cells haboring various KRAS mutants.
    SOS1/EGFR-IN-2
  • HY-161654
    PROTAC SOS1 degrader-10
    		Inhibitor
    PROTAC SOS1 degrader-10 (Compound 11o) is a degrader for son of sevenless 1 (SOS1) in a CRBN and proteasome dependent manner. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS mutant cancer cells SW620, A549 and DLD-1, with DC50s of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits the proliferations of cells SW620, A549 and DLD-1, with IC50s of 36.7, 52.2 and 107 nM, respectively. PROTAC SOS1 degrader-10 inhibits phosphorylation of ERK. (Pink: SOS1 ligand (HY-161655); Black: linker (HY-161656); Blue: E3 ligase ligand (HY-W249500))
    PROTAC SOS1 degrader-10
  • HY-176789
    VUBI1-octanoic acid
    		Inhibitor
    VUBI1-octanoic acid is a conjugate of SOS1 ligand and linker, which can be used in the synthesis of (4S)-PROTAC SOS1 degrader-1 (HY-144657).
    VUBI1-octanoic acid
  • HY-144207
    SOS1-IN-9
    		Inhibitor
    SOS1-IN-9 is a potent SOS1 inhibitor with an IC50 of 116.5 nM for SOS1-KRAS G12C (WO2022028506A1, compound 302).
    SOS1-IN-9
  • HY-144210
    SOS1-IN-6
    		Inhibitor
    SOS1-IN-6 (compound 33-P1) is a potent SOS1 inhibitor with IC50s of 14.9 and 73.3 nM for SOS1-G12D and SOS1-G12V, respectively.
    SOS1-IN-6
  • HY-161634
    PROTAC SOS1 degrader-8
    		Inhibitor
    PROTAC SOS1 degrader-8 (Compd 1) is a PROTAC-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161637)).
    PROTAC SOS1 degrader-8
  • HY-175326
    SOS1-IN-21
    		Inhibitor
    SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer.
    SOS1-IN-21
  • HY-P2265
    SAH-SOS1A
    		Inhibitor
    SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
    SAH-SOS1A
  • HY-168637
    SIAIS562055
    		Inhibitor
    SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRASG12C or KRASG12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638); Black: linker (HY-W539874); Blue: E3 ligase ligand (HY-W076696)).
    SIAIS562055
  • HY-169371
    SOS1 Ligand intermediate-7
    		Inhibitor
    SOS1 Ligand intermediate-7 (65) is an intermediate for the synthesis of SOS1 ligand (HY-111671). SOS1 activator 1 (HY-111671) can be used for the synthesis of PROTAC SOS1 degrader-1 (HY-145737).
    SOS1 Ligand intermediate-7
  • HY-144967
    SOS1-IN-13
    		Inhibitor
    SOS1-IN-13 is a potent son of sevenless homolog 1 (SOS1) inhibitor with IC50s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 can be used for researching anticancer.
    SOS1-IN-13
  • HY-161236
    KRAS ligand 4
    		Inhibitor
    KRAS ligand 4 (compound 2) is a bifunctional molecular glue degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations.
    KRAS ligand 4
  • HY-49515
    SOS1 Ligand intermediate-2
    		Inhibitor
    VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs.
    SOS1 Ligand intermediate-2
  • HY-163583
    SOS1 Ligand intermediate-6
    		Inhibitor
    SOS1 Ligand intermediate-6 is an intermediate for the synthesis of SOS1 ligand and can be used to synthesize PROTACs.
    SOS1 Ligand intermediate-6
  • HY-RS23001
    Sos1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Sos1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sos1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sos1 Rat Pre-designed siRNA Set A
  • HY-RS16568
    Sos1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Sos1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sos1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Sos1 Mouse Pre-designed siRNA Set A
  • HY-161655
    SOS1 Ligand intermediate-5
    		Inhibitor
    SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10 (HY-161654).
    SOS1 Ligand intermediate-5