2. Signaling Pathways
  3. MAPK/ERK Pathway
  4. SOS1
  5. SOS1 Activator

SOS1 Activator

SOS1 Activators (2):

Cat. No. Product Name Effect Purity
  • HY-167768
    SOS1 activator 2
    		Activator
    SOS1 activator 2 (Compound 65) is a benzimidazole derivative and a SOS1 activator. SOS1 activator 2 has a high binding affinity for SOS1 with a Kd of 9 nM. SOS1 activator 2 can regulate the Ras-ERK signaling pathway, which can be used in the study of cancer.
  • HY-111671
    VUBI1
    		Activator 98.01%
    VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 (HY-145737), to induce SOS1 degradation. VUBI1 can be used in the study of cancer.