2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. SHP2
  5. SHP2 Degrader

SHP2 Degrader

SHP2 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-173560
    SHP2 ATTEC degrader-1
    		Degrader
    SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker ( E-cadherin)， and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand (HY-174085); Black :linker HY-140468; Blue: SHP2 ligand (HY-174084).