2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. SHP1
  5. SHP1 Agonist

SHP1 Agonist

SHP1 Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-W717425
    SC-60
    		Agonist
    SC-60 is a derivative of Sorafenib (HY-10201). SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1, thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2, Cyclin D1, Survivin), ultimately inducing caspase-dependent apoptosis (apoptosis). SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC.