2. Signaling Pathways
  3. GPCR/G Protein
  4. RXFP Receptor
  5. RXFP Receptor Agonist

RXFP Receptor Agonist

RXFP Receptor Agonists (5):

Cat. No. Product Name Effect Purity
  • HY-P11246
    A13:B7-24-GG
    		Agonist
    A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a Ki value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (Ki = 602.56 nM) and an inhibitory effect on cAMP (EC50) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC50 of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation.
  • HY-176215
    RXFP1 receptor agonist-10
    		Agonist
    RXFP1 receptor agonist-10 (Compound 188) is a RXFP1 receptor agonist (EC50: 0.5 nM). RXFP1 receptor agonist-10 can be used for research of heart failure.
  • HY-P10728
    B7-33
    		Agonist 99.31%
    B7-33 is a single-chain relaxin mimetic. B7-33 is a selective relaxin receptor 1 (RXFP1) agonist. B7-33 binds to RXFP1 and preferentially activates thepERK pathway over cAMP in cells (with RXFP1 expression). B7-33 is an anti-fibrotic agent. B7-33 has cardioprotective effects.
  • HY-162401
    AZ7976
    		Agonist
    AZ7976 (Compound 42) is a highly selective agonist for the Relaxin Family Peptide Receptor 1 (RXFP1) (pEC50 > 10.5). AZ7976 enhances RXFP1's cAMP signaling through an allosteric mechanism, thereby physiologically increasing heart rate. AZ7976 can be used in the field of cardiovascular disease research.
  • HY-P991133
    Efranarelaxin alfa
    		Agonist
    Efranarelaxin alfa is a relaxin receptor agonist. Efranarelaxin alfa is promising for research of cardiovascular diseases and tissue repair.