2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan GPCR
  5. Orphan GPCR Inhibitor

Orphan GPCR Inhibitor

Orphan GPCR Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-160187
    AAA
    		Inhibitor 98.40%
    AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin.
  • HY-12664
    AF64394
    		Inhibitor 98.02%
    AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
  • HY-156354
    GPR61 Inverse agonist 1
    		Inhibitor 99.33%
    GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia.
  • HY-P991587
    SAR-446523
    		Inhibitor
    SAR-446523 is a humanized IgG1 monoclonal antibody inhibitor targeting GPRC5D. SAR-446523 significantly induces antibody-dependent cell-mediated cytotoxicity (ADCC). SAR-446523 has potent antitumor activity with improvement of mouse survival in NK humanized NOG huIL15 transgenic mice model bearing MM cells. SAR-446523 can be used for multiple myeloma (MM) research.
  • HY-P991726
    Vemzatatug
    		Inhibitor
    Vemzatatug is a humanized IgG1κ monoclonal antibody inhibitor targeting GPRC5D. Vemzatatug has an antitumor activity. Vemzatatug can be used for cancers like multiple myeloma (MM) research.